Product Description
The BioDeviceLab 50 nm Silica Nanoparticles are uniform, spherical inorganic nanomaterials engineered for advanced biological, analytical, and biodevice research. With a nominal particle diameter of ~50 nm, these nanoparticles provide enhanced mechanical robustness, reduced aggregation tendency, and controlled surface accessibility compared to smaller silica nanoparticles, supporting long-term and repeatable experimental workflows.
Silica nanoparticles are optically transparent across the visible spectrum and exhibit characteristic UV absorbance below ~230 nm, ensuring minimal interference with optical, electrochemical, and hybrid sensing platforms. Their chemically inert amorphous SiO₂ matrix makes them ideal as non-reactive scaffolds in biosensors, microfluidic devices, and lab-on-chip systems.
Manufactured under controlled synthesis conditions, these nanoparticles exhibit narrow size distribution and reproducible physicochemical properties. Supplied as a 500 mL aqueous dispersion, this product supports scalable assay development, surface chemistry optimization, and translational biodevice validation.
Intended Use
This product is intended for research applications including:
• Biosensor surface engineering and assay stabilization
• Biomolecule immobilization and linker chemistry development
• Drug delivery and nanocarrier research
• Microfluidic and lab-on-chip material integration
• Cell–nanomaterial interaction studies
• Reference nanomaterial for method development and benchmarking
Principle of Operation
Silica nanoparticles function as chemically inert, high-surface-area platforms for biological and chemical functionalization. The amorphous SiO₂ surface presents abundant silanol (–OH) groups that enable covalent attachment of proteins, antibodies, aptamers, polymers, and other ligands. The 50 nm particle size provides improved colloidal stability and handling robustness, reducing aggregation and supporting reproducible performance in extended experimental workflows.
Characterization & Quality Control
Particle size and morphology are verified by transmission electron microscopy (TEM). Hydrodynamic diameter and size dispersity are confirmed by dynamic light scattering (DLS), and zeta potential measurements assess colloidal stability. Standardized synthesis and quality control protocols ensure batch-to-batch reproducibility.
Analytical & Physical Characteristics
Nominal particle diameter: ~50 nm
Material: Amorphous silica (SiO₂)
Morphology: Spherical
Size dispersity: <15%
Surface chemistry: Native silica (–OH rich)
Optical properties: UV absorbance below ~230 nm; optically transparent in visible range
Dispersion medium: Aqueous
Supplied volume: 500 mL
Custom surface functionalization available upon request
Selectivity & Compatibility
Silica nanoparticles are chemically inert and broadly compatible with biological molecules, buffers, and common microfluidic materials. Their non-plasmonic, non-conductive nature minimizes assay interference, supporting optical, electrochemical, and biochemical platforms.
Package Contents
Each unit contains:
• 500 mL of 50 nm silica nanoparticle aqueous dispersion
• Particle characterization and quality control documentation
Required Materials (Not Provided)
• UV–Vis spectrophotometer (optional for UV characterization)
• DLS or TEM instrumentation (recommended)
• Standard laboratory glassware and pipettes
• Buffers suitable for downstream functionalization
Sample Handling & Use
Gently swirl before use to ensure uniform suspension. Avoid harsh agitation unless required for dispersion. Dilute with compatible buffers and handle using clean, contamination-free consumables.
Storage & Stability
Store at 4–25 °C. Do not freeze. Protect from prolonged contamination or evaporation. Stable under recommended storage conditions.
Limitations
For research use only. Not intended for diagnostic or therapeutic use. Performance may vary depending on surface modification strategy and experimental conditions.
Applications
• Biosensor and biodevice surface modification
• Microfluidic and lab-on-chip systems
• Nanomaterial–cell interaction studies
• Drug delivery and nanocarrier development
• Biodevice calibration and benchmarking
